94832-39-0

Basic information

• Product Name: 8-FLUORO-5-NITROQUINOLINE
• Synonyms: 8-FLUORO-5-NITROQUINOLINE
• CAS NO: 94832-39-0
• Molecular Formula: C9H5FN2O2
• Molecular Weight: 192.1
• Mol File: 94832-39-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 329.7 °C at 760 mmHg
• Flash Point: 153.2 °C
• Appearance: /
• Density: 1.446 g/cm³
• Vapor Pressure: 0.000335mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 8-FLUORO-5-NITROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-5-NITROQUINOLINE(94832-39-0)
• EPA Substance Registry System: 8-FLUORO-5-NITROQUINOLINE(94832-39-0)

Safety Data

• Hazardous Substances Data: 94832-39-0(Hazardous Substances Data)

Usage

General Description

8-FLUORO-5-NITROQUINOLINE is a chemical compound with the molecular formula C9H6FN3O2. It is a quinoline derivative, which contains a fluorine atom and a nitro group. 8-FLUORO-5-NITROQUINOLINE is widely used in organic synthesis and as a building block for the preparation of various pharmaceuticals and agrochemicals. It exhibits antimicrobial and antifungal properties, making it useful in the development of new drugs and treatments. Furthermore, 8-FLUORO-5-NITROQUINOLINE is also used in research and development in the fields of medicine, chemistry, and material science. Its unique structure and reactivity make it a valuable tool for scientists and researchers working on innovative solutions and products.

InChI:InChI=1/C9H5FN2O2/c10-7-3-4-8(12(13)14)6-2-1-5-11-9(6)7/h1-5H

Upstream product

• 394-68-3 8-fluoroquinoline 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 236093-01-9 3-fluoro-5-nitroquinoline-N-oxide 
• 175229-87-5 5-amino-8-fluoroquinoline 
• 191861-16-2 6-Fluoro-1,7-phenanthroline 

Relevant articles and documents

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

Dual stimulatory and inhibitory effects of fluorine-substitution on mutagenicity: An extension of the enamine epoxide theory for activation of the quinoline nucleus

Nineteen mono- and di-fluorinated derivatives of quinoline, 1,7- phenanthroline, 1,10-phenanthroline, benzo-[h]quinoline, and benzo[f]quinoline were subjected to analysis of their structure-mutagenicity relationships. For this purpose, six new fluorinated derivatives were synthesized. The results support that the enamine epoxide structure of the pyridine moiety, as well as the bay-region epoxide structure, is responsible for mutagenicity. Formation of K-region epoxides might involve a detoxification process rather than mutagenic activation.