94833-81-5Relevant articles and documents
Synthesis of 4-alkyl(aryl, hetaryl)-2-thioxo-5,6,7,8-tetrahydroquinoline-3- carbonitriles and their derivatives by cross-recyclization of 4-alkyl(aryl, hetaryl)-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles with 4-(cyclohex-1-en-1- yl)-morpholine, alkyl halides, and cyclohexanone
Dyachenko,Dyachenko
, p. 412 - 420 (2008/12/22)
Cross recyclization of 4-substituted 2,6-diamino-4H-thiopyran-3,5- dicarbonitriles with 4-(cyclohex-1-en-1-yl)morpholine, alkyl halides, and cyclohexanone gave the corresponding substituted 2-thioxo-1,2,5,6,7,8- hexahydroquinoline-3-carbonitriles, 2-alkylsulfanyl-5,6,7,8-tetrahydroquinoline- 3-carbonitriles, 3-amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2- carboxamides, and 4-oxo-2,2-pentamethylene-1,2,3,4,7,8,9,10- octahydropyrimido[4′,5′:4,5]thieno[2,3-b]quinolines. The structure of 3-(4-bromophenyl)-2,2-pentamethylene-11-(2-thienyl)-1,2,3,4,7,8,9,10- octahydropyrimido[4′,5′:4,5]thieno[2,3-b]quinoline was proved by X-ray analysis.
CYCLIZATION OF NITRILES. XXXV. ANNELLATION OF 2-ARYLIDENE-3-OXOQUINUCLIDINES TO 4-ARYL-3-CYANO-5,8-ETHANO-5,6,7,8-TETRAHYDRO-1,5-NAPHTHIRIDINE-2(1H)-THIONES
Shestopalov, A. M.,Mortikov, V. Yu.,Sharanin, Yu. A.,Turov, A. V.,Litvinov, V. P.
, p. 1789 - 1793 (2007/10/02)
The reaction of 2-arylidene-3-oxoquinuclidines with cyanothioacetamide in the presence of piperidine leads to the formation of piperidinio-4-aryl-3-cyano-5,8-ethano-1,4,5,6,7,8-hexahydro-1,5-naphthiridine-thiolates.The latter are dehydrogenated in an acidic medium to 4-aryl-3-cyano-5,8-ethano-5,6,7,8-tetrahydro-1,5-naphthiridine-2(1H)-thiones.In contrast, the analogous reaction of 2-arylidenecyclohexanones (ketones which do not contain the amino bridging fragment) takes place with dehydrogenation and leads to the formation of 4-aryl-3-cyano-2(1H)-quinolinethiones.Methods based on the obtained compounds were developed for the synthesis of the new annellated heterocycles thieno1,5-naphthiridine and thiazolo1,5-naphthiridine.
CONDENSED PYRIDINES COMMUNICATION 3. ARYLIDENETHIO(SELENO)ACETAMIDES IN THE SYNTHESIS OF 4-ARYL-3-CYANO-2-PYRIDINETHIONES AND 4-ARYl-3-CYANO-2PYRIDINESELENONES
Litvinov, V. P.,Promonenkov, V. K.,Sharanin, Yu. A.,Shestopalov, A. M.,Rodionovskaya, L. A.,et al.
, p. 1940 - 1947 (2007/10/02)
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