949524-35-0

Basic information

• Product Name: (E)-3-chloro-2-(4-fluoro-phenyl)-3-phenylacrylaldehyde
• CAS NO: 949524-35-0
• Molecular Weight: 260.695
• Mol File: 949524-35-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-chloro-2-(4-fluoro-phenyl)-3-phenylacrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-chloro-2-(4-fluoro-phenyl)-3-phenylacrylaldehyde(949524-35-0)
• EPA Substance Registry System: (E)-3-chloro-2-(4-fluoro-phenyl)-3-phenylacrylaldehyde(949524-35-0)

Safety Data

• Hazardous Substances Data: 949524-35-0(Hazardous Substances Data)

Upstream product

• 459-04-1 4-Fluorophenylacetyl chloride 
• 71-43-2 benzene 
• 347-91-1 2-(4-fluorophenyl)-1-phenylethanone 

Relevant articles and documents

Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hypercholesterolemia. Herein, we describe an efficient synthesis of its highly functionalized pyrrole core followed by attachment of the 3,5-dihydroxyhexanoic acid side chain via ylide olefination chemistry.