949588-03-8

Basic information

• Product Name: benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate
• Synonyms: benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate
• CAS NO: 949588-03-8
• Molecular Weight: 473.61
• Mol File: 949588-03-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate(949588-03-8)
• EPA Substance Registry System: benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate(949588-03-8)

Safety Data

• Hazardous Substances Data: 949588-03-8(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 146004-98-0 16-(benzyloxy)-16-oxohexadecanoic acid 
• 100-51-6 benzyl alcohol 
• 1460-18-0 pentadecanedioic acid 
• 1034470-47-7 hexadecanedioic acid-anhydride 
• 105832-38-0 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 

Downstream Products

• 949588-04-9 benzylhexadecandioyl-L-Glu-OBn 
• 949588-05-0 benzylhexadecandioyl-L-Glu(OSu)-OBn 

Relevant articles and documents

Method for preparing long aliphatic chain diacid derivative and application of long aliphatic chain diacid derivative

The invention provides a method for preparing a long aliphatic chain diacid derivative. The method comprises the following steps of: (1) carrying out a cyclization reaction on long aliphatic chain diacid, the long aliphatic chain diacid having a structure as shown in a formula (A); (2) reacting the long aliphatic chain diacid cyclization product with benzyl alcohol to obtain long aliphatic chain diacid monobenzyl ester; (3) carrying out an esterification reaction on the long aliphatic chain diacid monobenzyl ester and N-hydroxysuccinimide so as to obtain long aliphatic chain diacid succinimide benzyl ester; (4) carrying out a nucleophilic addition amidation reaction on the long aliphatic chain diacid succinimide benzyl ester and a compound as shown in a formula (B) to obtain a compound as shown in a formula (C); (5) carrying out an esterification reaction on the compound as shown in the formula (C) and N-hydroxysuccinimide again so as to obtain a compound as shown in a formula (D); and (6) carrying out a debenzylation reaction on the compound shown in the formula (D) so as to obtain a compound shown in a formula (E).

CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY

The present disclosure provides conjugates that comprise an insulin molecule conjugated via a conjugate framework to two or more separate ligands that each include a saccharide, wherein the framework, ligand, saccharide and insulin molecule optionally com