949931-37-7Relevant articles and documents
N-acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRβ
Molteni, Valentina,Li, Xiaolin,Nabakka, Juliet,Liang, Fang,Wityak, John,Koder, Alan,Vargas, Leo,Romeo, Russell,Mitro, Nico,Mak, Puiying A.,Seidel, H. Martin,Haslam, Jennifer A.,Chow, Donald,Tuntland, Tove,Spalding, Tracy A.,Brock, Ansgar,Bradley, Michelle,Castrillo, Antonio,Tontonoz, Peter,Saez, Enrique
, p. 4255 - 4259 (2008/02/13)
We have identified a novel liver X receptor (LXR) agonist (2) that activates the LXRβ subtype with selectivity over LXRα. LXRβ selectivity was confirmed using macrophages derived from LXR mutant mice. Despite its selectivity and modest potency, the compou