95021-64-0

Basic information

• Product Name: 2,5-Piperazinedione, 1,4-bis[(4-methylphenyl)sulfonyl]-
• CAS NO: 95021-64-0
• Molecular Formula: C18H18N2O6S2
• Molecular Weight: 422.483
• Mol File: 95021-64-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-Piperazinedione, 1,4-bis[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione, 1,4-bis[(4-methylphenyl)sulfonyl]-(95021-64-0)
• EPA Substance Registry System: 2,5-Piperazinedione, 1,4-bis[(4-methylphenyl)sulfonyl]-(95021-64-0)

Safety Data

• Hazardous Substances Data: 95021-64-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 56218-62-3 2-(4-methylphenylsulfonamido)acetyl chloride 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 56-40-6 glycine 
• 1080-44-0 N-Tosylglycine 

Relevant articles and documents

Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease

Novel multifunctional 3,6-Diphenyl-1,4-bis(phenylsulfonyl)piperazine-2,5-dione derivatives were designed and synthesized for the treatment of Alzheimer's disease (AD). The designed scaffold has blood brain barrier penetrating ability, acetylcholinesterase (AChE) and matrix metalloproteinase-2 (MMP-2) inhibition potential. Compounds 52 and 46 showed very significant inhibition against AChE, IC50 = 32.45 ± 0.044, 28.65 ± 0.029, BuChE, IC50 = 157.95 ± 0.264, 160.58 ± 0.082 and MMP-2, IC50 = 36.83 ± 0.015, 19.57 ± 0.005 (nM). In the enzyme kinetics study, lead molecule 46 showed non-competitive inhibition of AChE with Ki = 7 nM and competitive inhibition of MMP-2 with Ki = 20 nM. Compounds 52 and 46 inhibited AChE-induced Aβ aggregation at 20 μM. The compounds also exhibited in-vitro antioxidant potential in DPPH assay. Further, compound 46 was found to be a promising neuroprotective agent in MC65 cells. Lead molecule 46 significantly enhanced working memory in scopolamine induced amnesia animal model at dose of 5 mg/kg dose. The mitochondrial membrane potential was restored in animals when treated with compounds 52 and 46.