950683-55-3 Usage
Description
t-Boc-N-Amido-PEG2-Azide is a versatile PEG (polyethylene glycol)-based linker that features an azide functional group and a Boc-protected amine. t-Boc-N-Amido-PEG2-Azide is designed to participate in Click Chemistry reactions with alkyne and BCN (bicyclo[6.1.0]nonyne) or DBCO (dibenzocyclooctyne) moieties, allowing for the efficient and selective formation of triazole linkages. The Boc group present in the molecule can be removed under mild acidic conditions, revealing the free amine for further functionalization or conjugation. t-Boc-N-Amido-PEG2-Azide is a light yellow oil, which makes it suitable for a variety of applications in chemical biology and medicinal chemistry.
Uses
Used in Bioconjugation:
t-Boc-N-Amido-PEG2-Azide is used as a bioconjugation agent for the attachment of various biomolecules, such as peptides, proteins, and nucleic acids, to other molecules or surfaces. The PEG spacer provides increased solubility and stability, while the azide group enables efficient and selective coupling through Click Chemistry.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Boc-N-Amido-PEG2-Azide is used as a component in drug delivery systems to improve the pharmacokinetics and biodistribution of therapeutic agents. The PEGylation of drugs can enhance their solubility, circulation time, and bioavailability, while the azide group allows for the attachment of targeting ligands or imaging agents through Click Chemistry.
Used in Chemical Biology:
t-Boc-N-Amido-PEG2-Azide is employed as a building block in the development of chemical probes and tools for biological research. The PEG linker can be used to attach small molecules or other functional groups to biomolecules, enabling the study of their interactions and activities in cellular and molecular contexts.
Used in Materials Science:
In the field of materials science, t-Boc-N-Amido-PEG2-Azide is used as a component in the synthesis of functional polymers and materials. The PEG-based linker can be incorporated into polymer structures to impart properties such as hydrophilicity, biocompatibility, and self-assembly behavior, while the azide group allows for the subsequent attachment of other functional groups or moieties through Click Chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 950683-55-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,0,6,8 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 950683-55:
(8*9)+(7*5)+(6*0)+(5*6)+(4*8)+(3*3)+(2*5)+(1*5)=193
193 % 10 = 3
So 950683-55-3 is a valid CAS Registry Number.
950683-55-3Relevant articles and documents
COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF
-
, (2020/09/03)
Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a -S(=0)(=N-)- functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.
Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs
Howarth, Nicola M.,Ricci, Jennyfer
, p. 9588 - 9594 (2011/12/14)
Application of the click reaction for coupling a 2-(2-aminoethoxy)ethoxy (AEE) function to thyminyl, cytosinyl and adeninyl peptide nucleic acid (PNA) monomer analogues bearing a N-propynyl group, in place of the original N-2-aminoethyl moiety, has been explored. The N-propynyl PNA analogues were prepared from glycine ethyl ester hydrochloride and the structure of the thyminyl derivative was confirmed by X-ray diffraction. These monomers were employed in click reactions with Boc-protected AEE azide to afford the corresponding triazolyl-linked PNA-AEE conjugates in yields ranging from 64 to 76%. [1,4]-Regiochemistry was verified from a NOESY correlation experiment.
