950818-63-0

Basic information

• Product Name: CH₂OC₁₄H₁₉ON
• Synonyms: CH₂OC₁₄H₁₉ON
• CAS NO: 950818-63-0
• Molecular Weight: 247.337
• Mol File: 950818-63-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: CH₂OC₁₄H₁₉ON(CAS DataBase Reference)
• NIST Chemistry Reference: CH₂OC₁₄H₁₉ON(950818-63-0)
• EPA Substance Registry System: CH₂OC₁₄H₁₉ON(950818-63-0)

Safety Data

• Hazardous Substances Data: 950818-63-0(Hazardous Substances Data)

Upstream product

• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 42465-54-3 1-(2-amino-3-methoxyphenyl)ethanone 
• 693-02-7 hex-1-yne 
• 33852-43-6 1-(3-methoxy-2-nitrophenyl)ethanone 

Downstream Products

• 1192743-85-3 2-methoxy-6-(1-methylenehept-2-ynyl)aniline 

Relevant articles and documents

Recyclable catalytic synthesis of substituted quinolines: copper-catalyzed heterocyclization of 1-(2-aminoaryl)-2-yn-1-ols in ionic liquids

A convenient and simple approach for the recyclable catalytic synthesis of substituted quinolines is presented. The method is based on CuCl2-catalyzed heterocyclization of readily available 1-(2-aminoaryl)-2-yn-1-ols in BmimBF4 as the solvent at 100 °C for 15-24 h. The solvent-catalyst system could be successfully recycled up to six times without significant loss of activity.

Novel and convenient synthesis of substituted quinolines by copper- or palladium-catalyzed cyclodehydration of 1-(2-aminoaryl)-2-yn-1-ols

(Chemical Equation Presented) A general and convenient synthesis of substituted quinolines by regioselective copper- or palladium-catalyzed 6-endo-dig cyclization-dehydration of 1-(2-aminoaryl)-2-yn-1-ols is reported. The crude substrates were easily obtained by the Grignard reaction between the appropriate alkynylmagnesium bromide and 2-aminoaryl ketones and could be used without further purification for the subsequent cyclization step. Heteroannulation reactions were carried out in MeOH or DME as the solvent at 60 or 100°C in the presence of CuCl2 or PdX2 (in conjunction with 10 equiv of KX, X = Cl, I) as the catalyst to afford the quinoline derivatives in good to excellent isolated yields based on starting 1-(2-aminoaryl)-2-yn-1-ols (66-90%).