950818-67-4

Basic information

• Product Name: C₁₄H₁₅ONC₂CH₂O
• Synonyms: C₁₄H₁₅ONC₂CH₂O
• CAS NO: 950818-67-4
• Molecular Weight: 267.327
• Mol File: 950818-67-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₅ONC₂CH₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₅ONC₂CH₂O(950818-67-4)
• EPA Substance Registry System: C₁₄H₁₅ONC₂CH₂O(950818-67-4)

Safety Data

• Hazardous Substances Data: 950818-67-4(Hazardous Substances Data)

Upstream product

• 42465-54-3 1-(2-amino-3-methoxyphenyl)ethanone 
• 536-74-3 phenylacetylene 
• 33852-43-6 1-(3-methoxy-2-nitrophenyl)ethanone 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Downstream Products

• 1039105-96-8 8-methoxy-4-methyl-2-phenylquinoline-3-carboxylic acid methyl ester 

Relevant articles and documents

Novel and convenient synthesis of substituted quinolines by copper- or palladium-catalyzed cyclodehydration of 1-(2-aminoaryl)-2-yn-1-ols

(Chemical Equation Presented) A general and convenient synthesis of substituted quinolines by regioselective copper- or palladium-catalyzed 6-endo-dig cyclization-dehydration of 1-(2-aminoaryl)-2-yn-1-ols is reported. The crude substrates were easily obtained by the Grignard reaction between the appropriate alkynylmagnesium bromide and 2-aminoaryl ketones and could be used without further purification for the subsequent cyclization step. Heteroannulation reactions were carried out in MeOH or DME as the solvent at 60 or 100°C in the presence of CuCl2 or PdX2 (in conjunction with 10 equiv of KX, X = Cl, I) as the catalyst to afford the quinoline derivatives in good to excellent isolated yields based on starting 1-(2-aminoaryl)-2-yn-1-ols (66-90%).