951154-47-5Relevant articles and documents
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors
Lee, Shoukou,Shinji, Chihiro,Ogura, Kiyoshi,Shimizu, Motomu,Maeda, Satoko,Sato, Mayumi,Yoshida, Minoru,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 4895 - 4900 (2008/02/11)
We designed and synthesized hydroxamic acid derivatives bearing a 4-(3-pyridyl)phenyl group as a cap structure, and found that they exhibit potent histone deacetylase (HDAC) inhibitory activity. A representative compound, 17a, showed more potent growth-in
