951163-61-4

Basic information

• Product Name: Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester
• Synonyms: Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester;N-[(3S,5S)-5-Methyl-3-piperidinyl]carbamic acid tert-butyl ester;N-[(3S,5S)-5-Methyl-3-piperidinyl]-carbaMic acid 1,1-diMethylethyl ester;tert-butyl (3S,5S)-5-methylpiperidin-3-ylcarbamate
• CAS NO: 951163-61-4
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.3
• Product Categories: API intermediates
• Mol File: 951163-61-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 313℃
• Flash Point: 143℃
• Appearance: /
• Density: 1.00
• PKA: 12.38±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester(951163-61-4)
• EPA Substance Registry System: Carbamic acid, N-[(3S,5S)-5-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester(951163-61-4)

Safety Data

• Hazardous Substances Data: 951163-61-4(Hazardous Substances Data)

Usage

Uses

tert-Butyl ((3S,5S)-5-Methylpiperidin-3-yl)carbamate is used in the synthetic preparation of pyrrolopyrazinylureas as JAK kinase inhibitors for the treatment of autoimmune and inflammatory diseases.

Upstream product

• 951163-63-6 (3S,5S)-(1-benzyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester 
• 59279-60-6 dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate 
• 74-88-4 methyl iodide 
• 1229616-47-0 (2S,4S)-2-tert-butoxycarbonylamino-4-methyl-pentanedinitrile 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1270019-95-8 (3S,5S)-(5-Methyl-piperidin-3-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Preparation method of 3-substituted-5-aminopiperidine with protecting group

The invention provides a preparation method of 3-substituted-5-aminopiperidine with a protecting group, and particularly provides a preparation method of 3-substituted-5-aminopiperidine with a protecting group, which has the advantages of low cost and easily available raw materials and reaction reagents.

STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES

This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.

Coupling process for preparing quinolone intermediates

Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process.