951219-66-2Relevant articles and documents
Synthesis and structure-activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents
Sakaki, Junichi,Kishida, Masashi,Konishi, Kazuhide,Gunji, Hiroki,Toyao, Atsushi,Matsumoto, Yuki,Kanazawa, Takanori,Uchiyama, Hidefumi,Fukaya, Hiroaki,Mitani, Hironobu,Arai, Yoshie,Kimura, Masaaki
, p. 4804 - 4807 (2008/09/19)
A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assay of the transactivation of RXR. Oral treatment of cyano derivatives (16f) was found to show anti-diabetic and anti-obesity effects in KK-Ay mice.