951771-57-6Relevant articles and documents
Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity
Spanka, Carsten,Glatthar, Ralf,Desrayaud, Sandrine,Fendt, Markus,Orain, David,Troxler, Thomas,Vranesic, Ivo
scheme or table, p. 184 - 188 (2010/04/24)
High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivit