95216-46-9

Basic information

• Product Name: 1-[4-(carboxymethyl)phenyl]-2-isopropyl-4(1H)-quinazolinone
• Synonyms: 1-[4-(carboxymethyl)phenyl]-2-isopropyl-4(1H)-quinazolinone
• CAS NO: 95216-46-9
• Molecular Weight: 322.364
• Mol File: 95216-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(carboxymethyl)phenyl]-2-isopropyl-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(carboxymethyl)phenyl]-2-isopropyl-4(1H)-quinazolinone(95216-46-9)
• EPA Substance Registry System: 1-[4-(carboxymethyl)phenyl]-2-isopropyl-4(1H)-quinazolinone(95216-46-9)

Safety Data

• Hazardous Substances Data: 95216-46-9(Hazardous Substances Data)

Upstream product

• 95216-45-8 1-(4-Acetyl-phenyl)-2-isopropyl-1H-quinazolin-4-one 
• 95216-62-9 2-(4-acetylanilino)benzamide 
• 37960-65-9 potassium anthranilate 
• 99-90-1 para-bromoacetophenone 
• 23600-82-0 N-(4-acetylphenyl)anthranilic acid 
• 95216-70-9 2-isopropyl-1-<4-<(morpholinothiocarbonyl)methyl>phenyl>-4(1H)-quinazolinone 

Relevant articles and documents

Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives

A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.