952188-00-0

Basic information

• Product Name: Pioglitazone Impurity
• Synonyms: Pioglitazone Impurity;Pioglitazone EP IMpurity C;5-[4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]thiazolidine-2,4-dione;Pioglitazone IMpurity C;5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-N-[2-(5-ethylpyridin-2-yl)ethyl]-2,4-thiazolidinedione
• CAS NO: 952188-00-0
• Molecular Formula: C₂₈H₃₁N₃O₃S
• Molecular Weight: 489.62904
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 952188-00-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 85-87°C
• Boiling Point: 663.3°C at 760 mmHg
• Flash Point: 354.9°C
• Appearance: /
• Density: 1.217
• Vapor Pressure: 1.84E-17mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: Pioglitazone Impurity(CAS DataBase Reference)
• NIST Chemistry Reference: Pioglitazone Impurity(952188-00-0)
• EPA Substance Registry System: Pioglitazone Impurity(952188-00-0)

Safety Data

• Hazardous Substances Data: 952188-00-0(Hazardous Substances Data)

Usage

Description

Pioglitazone Impurity is a substance that is produced during the manufacturing process of Pioglitazone, a medication used to treat type 2 diabetes. It is a byproduct that can affect the purity and efficacy of the final product.

Uses

Used in Pharmaceutical Industry:
Pioglitazone Impurity is used as a reference material for quality control and analytical testing in the pharmaceutical industry. It helps ensure the purity and potency of Pioglitazone medications, ensuring that they meet regulatory standards and are safe for patients to use.
Used in Research and Development:
Pioglitazone Impurity is also used in research and development for the study of the properties and effects of Pioglitazone. This can help scientists and researchers better understand the drug's mechanism of action, potential side effects, and ways to improve its efficacy and safety.
Used in Regulatory Compliance:
Pioglitazone Impurity is used in regulatory compliance to ensure that pharmaceutical companies adhere to strict guidelines and standards for drug manufacturing. It helps maintain the integrity and quality of medications, protecting patients from potential harm caused by impurities or contamination.

InChI:InChI=1/C28H31N3O3S/c1-3-20-5-9-23(29-18-20)13-15-31-27(32)26(35-28(31)33)17-22-7-11-25(12-8-22)34-16-14-24-10-6-21(4-2)19-30-24/h5-12,18-19,26H,3-4,13-17H2,1-2H3

Upstream product

• 105355-27-9 Pioglitazone 
• 144809-27-8 toluene-4-sulfonic acid 2-(5-ethylpyridin-2-yl)ethyl ester 
• 144809-26-7 2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate 
• 2295-31-0 thiazoline-2,4-dione 
• 114393-97-4 4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde 

Relevant articles and documents

Method for preparing pioglitazone impurity C by one-pot process

The invention discloses a method for preparing a pioglitazone impurity C by a one-pot process. The method comprises the following step: by using 4-[2-(5-ethyl-2-pyridyl)ethoxy]benzaldehyde, ethyl (5-ethyl-2-pyridyl) methanesulfonate and 2,4-thiazolidinyl dione as raw materials, carrying out reaction by a one-pot process to obtain the pioglitazone impurity C. The method has the advantages of mild reaction conditions, simple technique, short reaction time, fewer byproducts and high yield, and can obtain the high-purity pioglitazone impurity C.