95250-49-0

Basic information

• Product Name: 3,7-dihydro-1,3-dimethyl-7-<4-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-butenyl>-1H-purine-2,6-dione
• CAS NO: 95250-49-0
• Molecular Weight: 468.623
• Mol File: 95250-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,7-dihydro-1,3-dimethyl-7-<4-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-butenyl>-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-dihydro-1,3-dimethyl-7-<4-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-butenyl>-1H-purine-2,6-dione(95250-49-0)
• EPA Substance Registry System: 3,7-dihydro-1,3-dimethyl-7-<4-<4-<3-(phenylthio)propyl>piperazin-1-yl>-2-butenyl>-1H-purine-2,6-dione(95250-49-0)

Safety Data

• Hazardous Substances Data: 95250-49-0(Hazardous Substances Data)

Upstream product

• 95250-76-3 (E)-7-(4-chloro-2-buten-1-yl)theophylline 
• 65489-00-1 N(3-phenylthio-1-propyl)piperazine 
• 108-98-5 thiophenol 
• 57533-87-6 1,3-Dimethylxanthine potassium salt 
• 4911-65-3 3-chloropropyl phenyl sulfide 

Relevant articles and documents

New Antihistaminic Theophylline or Theobromine Derivatives

A series of 3,4-dihydro-1,3-dimethyl-7--1H-purine-2,6-diones and 3,7-dihydro-3,7-dimethyl-1--1H-purine-2,6-diones was synthesized and evaluated for antihistaminic activity.Some of them displayed good inhibition of both histamine-induced bronchospasm in the anesthetized guinea pig at 10 μ/kg by the intravenous route and of passive cutaneous anaphylaxis in the rat at 10 mg/kg by the oral route.Comparison of the two most active compounds revealed a higher antihistaminic activity with the compounds containing a (phenylthio)propyl group (1 and 2) as compared with that containing a phenoxy group.Compound 2 piperazin-1-yl>-2-hydroxypropyl>-1H-purine-2,6-dione> was selected for clinical trials on the basis of a comparative pharmacological study with chloropheniramine, ketotifen, promethazine, and theophylline.