95298-47-8

Basic information

• Product Name: Kaji-ichigoside F1
• Synonyms: 2α,3α,19α-Trihydroxyurs-12-en-28-oic acid (β-D-glucopyranosyl) ester;2α,3α,19α-Trihydroxyurs-12-ene-28-oic acid β-D-glucopyranosyl ester;Kaji-ichigoside F1;2alpha,3alpha,19alpha-Trihydroxylurs-12-en-28-oic acid-28-O-beta-D-glucopyranoside;28-O-beta-D-Glucopyranosyleuscaphic acid;2α,3α,19-Trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester;28-O-β-D-Glucopyranosyleuscaphic acid;2α,3α,19α-Trihydroxylurs-12-en-28-oic aicd-28-O-β-D-glucopyranoside
• CAS NO: 95298-47-8
• Molecular Formula: C₃₆H₅₈O₁₀
• Molecular Weight: 650.83972
• Mol File: 95298-47-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 230-232 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
• Boiling Point: 741.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• PKA: 12.52±0.70(Predicted)
• CAS DataBase Reference: Kaji-ichigoside F1(CAS DataBase Reference)
• NIST Chemistry Reference: Kaji-ichigoside F1(95298-47-8)
• EPA Substance Registry System: Kaji-ichigoside F1(95298-47-8)

Safety Data

• Hazardous Substances Data: 95298-47-8(Hazardous Substances Data)

Usage

Description

Kaji-ichigoside F1 is a triterpenoid compound that is isolated from the root of Rosa laevigata, a plant species known for its medicinal properties. It possesses both antibacterial and cytotoxic properties, making it a potential candidate for various applications in the pharmaceutical and healthcare industries.

Uses

Used in Pharmaceutical Industry:
Kaji-ichigoside F1 is used as an antibacterial agent for its ability to inhibit the growth of certain bacteria, which can be useful in treating bacterial infections and promoting overall health.
Used in Cancer Research and Treatment:
Kaji-ichigoside F1 is used as a cytotoxic triterpenoid for its potential to target and eliminate cancer cells. Its cytotoxic properties make it a promising candidate for further research and development in the field of cancer treatment.

Upstream product

• 508-02-1 Oleanolic acid 
• 1309589-79-4 2α,19α-dihydroxy-5α,9α-urs-12-en-3-one-28-oic acid-28-O-β-D-glucopyranosyl ester 

Downstream Products

• 13850-16-3 euscaphic acid 

Relevant articles and documents

Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina

A methanol extract from the tuberous roots of Potentilla anserina (Rosaceae) exhibited hepatoprotective effects against d-galactosamine (d-GalN)/lipopolysaccharide-induced liver injuries in mice. Six triterpene 28-O-monoglucopyranosyl esters, potentillanosides A-F, were isolated from the extract along with 32 known compounds, including 15 triterpenes. The structures of potentillanosides A-F were determined on the basis of spectroscopic properties and chemical evidence. Four ursane-type triterpene 28-O-monoglycosyl esters, potentillanoside A (IC50 = 46.7 μM), 28-O-β-d- glucopyranosyl pomolic acid (IC50 = 9.5 μM), rosamutin (IC 50 = 35.5 μM), and kaji-ichigoside F1 (IC50 = 14.1 μM), inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes. Among these four triterpenes, potentillanoside A, rosamutin, and kaji-ichigoside F1 exhibited in vivo hepatoprotective effects at doses of 50-100 mg/kg, p.o. The mode of action was ascribable to the reduction in cytotoxicity caused by d-GalN.