953-90-2

Basic information

• Product Name: 2-(4-aminobenzenesulfonylamido)-5-methylthiazole
• Synonyms: 2-(4-aminobenzenesulfonylamido)-5-methylthiazole
• CAS NO: 953-90-2
• Molecular Weight: 269.348
• Mol File: 953-90-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-aminobenzenesulfonylamido)-5-methylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aminobenzenesulfonylamido)-5-methylthiazole(953-90-2)
• EPA Substance Registry System: 2-(4-aminobenzenesulfonylamido)-5-methylthiazole(953-90-2)

Safety Data

• Hazardous Substances Data: 953-90-2(Hazardous Substances Data)

Usage

Chemical class

Thiazole

Type of compound

Heterocyclic

Key structural features

A thiazole ring with a substituted amino group

Common uses

Reagent in organic synthesis and pharmaceutical research

Potential therapeutic applications

Anti-inflammatory and antifungal agent, treatment of various medical conditions

Other studied properties

Antimicrobial and anticancer activities

Versatility

Wide range of potential applications in medicine and pharmacology

Upstream product

• 41731-23-1 2-bromo-5-methyl-1,3-thiazole 
• 63-74-1 sulfanilamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 88614-86-2 N-acetyl-sulfanilic acid-(5-methyl-thiazol-2-ylamide) 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 855230-93-2 4-nitro-N-5-methyl-thiazol-2-yl-benzenesulfonamide 

Relevant articles and documents

Ultrasound accelerated sulfonylation of amines by p-acetamidobenzenesulfonyl chloride using Mg–Al hydrotalcite as an efficient green base catalyst

The sulfonylation reaction of various aliphatic, alicyclic, aromatic, and hetero-aromatic amines with p-acetamidobenzenesulfonyl chloride has been investigated using different types of base catalysis under varied reaction conditions. Mg–Al hydrotalcite, characterizable as an inexpensive, reusable, and green solid catalyst, was found to be the most efficient catalyst, when the reaction is carried out in a minimum volume of solvent (acetone). The reaction was found to be accelerated drastically with the support of ultrasound irradiation, affording the sulfonamides in yields better or equivalent to those obtained under the longer lasting conventional stirring conditions.

MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF

Disclosed are an assay to identify modulators of the PD-1 :PD-L pathway and PD-1 :PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1 :PD-L pathway such as, for example, autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, immune deficiency, and other immune system-related disorders, are also disclosed.