953081-79-3

Basic information

• Product Name: methyl 2-[3,5-bis(trifluoromethylsulfonyloxy)phenyl]acetate
• Synonyms: methyl 2-[3,5-bis(trifluoromethylsulfonyloxy)phenyl]acetate
• CAS NO: 953081-79-3
• Molecular Weight: 446.302
• Mol File: 953081-79-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2-[3,5-bis(trifluoromethylsulfonyloxy)phenyl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[3,5-bis(trifluoromethylsulfonyloxy)phenyl]acetate(953081-79-3)
• EPA Substance Registry System: methyl 2-[3,5-bis(trifluoromethylsulfonyloxy)phenyl]acetate(953081-79-3)

Safety Data

• Hazardous Substances Data: 953081-79-3(Hazardous Substances Data)

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 4724-10-1 methyl 2-(3,5-dihydroxyphenyl)acetate 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 67562-21-4 4,4,5,5-tetramethyl-2-pentyl-1,3,2-dioxaborolane 

Relevant articles and documents

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DIABETES

The present invention concerns the use of compounds for preventing and/or treating diabetes, for modulating glucose, insulin, and/or triglyceride levels; for reducing blood glucose level; for maintaining or increasing insulin level; for increasing insulin secretion; increasing insulin sensitivity; or decreasing insulin resistance in a subject. These novel uses have been found for compounds represented by Formula I and pharmaceutically acceptable salts. wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2 C(O)OH, 4) CH(F)- C(O)OH, 5) CF2- C(O)OH, or 6) C(O)- C(O)OH.

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION

Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F of OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(0)OH wherein m is 1 or 2 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH or 6) C(0)-C(0)OH.

PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE

The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R0, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.