95337-74-9

Basic information

• Product Name: 2-Pyridinamine,6-butyl-(9CI)
• Synonyms: 2-Pyridinamine,6-butyl-(9CI);6-butylpyridin-2-amine
• CAS NO: 95337-74-9
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• Product Categories: AMINEPRIMARY
• Mol File: 95337-74-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253.7°C at 760 mmHg
• Flash Point: 130.8°C
• Appearance: /
• Density: 0.996g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 2-Pyridinamine,6-butyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine,6-butyl-(9CI)(95337-74-9)
• EPA Substance Registry System: 2-Pyridinamine,6-butyl-(9CI)(95337-74-9)

Safety Data

• Hazardous Substances Data: 95337-74-9(Hazardous Substances Data)

Usage

General Description

2-Pyridinamine,6-butyl-(9CI) is a chemical compound with the molecular formula C11H16N2. It is a derivative of pyridine and contains a butyl group attached to the sixth carbon atom of the pyridine ring. 2-Pyridinamine,6-butyl-(9CI) is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It has also been studied for its potential biological and pharmacological activities, including its antifungal and antibacterial properties. Overall, 2-Pyridinamine,6-butyl-(9CI) is a versatile chemical with diverse applications in the field of organic chemistry and drug discovery.

InChI:InChI=1/C9H14N2/c1-2-3-5-8-6-4-7-9(10)11-8/h4,6-7H,2-3,5H2,1H3,(H2,10,11)

Upstream product

• 95337-75-0 6-Butyl-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine 
• 32570-89-1 2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 1309921-20-7 N-(6-butylpyridin-2-yl)acetamide 
• 1309921-19-4 2-bromo-6-butylpyridine 

Downstream Products

• 1309921-02-5 3-cyano-5-fluoro-N-(6-butylpyridin-2-yl)benzamide 

Relevant articles and documents

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5

Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amide-based positive allosteric modulators, optimized substitution of the aryl bring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides.

Protection of Primary Amines as N-Substituted 2,5-Dimethylpyrroles

Protection of primary amine group is achieved by incorporating it into an N-substituted 2,5-dimethylpyrrole system.The method affords protection against strong bases and nucleophiles, heating with concentrated alkali, standard mineral acid work-up conditions, and various other reagents.Phenyl-, pyridil-, thiazolyl-, and alkyl-amines have been studied.All give trisubstituted pyrroles in high yield (>80percent) by reaction with hexane-2,5-dione.The pyrroles from the first three types are stable to storage; even the N-alkyl compounds can be used without difficulty.Regeneration of the amine group, by treatment with hydrxylamine hydrochloride, is efficient (80percent yield) with the phenyl, pyridyl, and alkyl compounds but less satisfactory (60 - 65percent generally but down to 25percent in two cases) with the thiazolyl derivatives.