953421-74-4

Basic information

• Product Name: Isoquinoline, 4-broMo-1,7-dichloro-
• Synonyms: Isoquinoline, 4-broMo-1,7-dichloro-;4-bromo-1,7-dichloroIsoquinoline
• CAS NO: 953421-74-4
• Molecular Formula: C₉H₄BrCl₂N
• Molecular Weight: 276.94476
• Mol File: 953421-74-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Isoquinoline, 4-broMo-1,7-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 4-broMo-1,7-dichloro-(953421-74-4)
• EPA Substance Registry System: Isoquinoline, 4-broMo-1,7-dichloro-(953421-74-4)

Safety Data

• Hazardous Substances Data: 953421-74-4(Hazardous Substances Data)

Usage

Description

Isoquinoline, 4-broMo-1,7-dichlorois a chemical compound that belongs to the isoquinoline family. It is characterized by the presence of a bromine atom at the 4th position and two chlorine atoms at the 1st and 7th positions. Isoquinoline, 4-broMo-1,7-dichlorohas unique chemical properties and is used in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
Isoquinoline, 4-broMo-1,7-dichlorois used as a reagent in the discovery of Asunaprevir (BM-650032), a potent inhibitor of NS3 Protease for hepatitis C virus infection. Isoquinoline, 4-broMo-1,7-dichloroplays a crucial role in the development of antiviral drugs that target and inhibit the activity of essential viral enzymes, thereby helping to combat the hepatitis C virus and its associated health complications.

Upstream product

• 21900-40-3 5-chloro-2-methylbenzoyl chloride 
• 7499-06-1 5-chloro-2-methylbenzoic acid 
• 1028252-11-0 5-chloro-2-methylbenzamide 
• 24188-74-7 7-chloroisoquinolin-1-ol 
• 1615-02-7 p-chlorocinnamic acid 
• 1028252-13-2 4-bromo-7-chloro-2H-isoquinolin-1-one 
• 24188-74-7 7-chloroisoquinoline-1(2Η)-one 
• 26386-88-9 diphenyl phosphoryl azide 
• 1028252-13-2 4-bromo-7-chloroisoquinolin-1-ol 
• 953421-73-3 4-bromo-7-chloroisoquinoline 2-oxide 

Downstream Products

• 630423-36-8 1,7-dichloro-4-methoxyisoquinoline 
• 630420-16-5 tert-butyl ((S)-1-((2S,4R)-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate 
• 1028252-15-4 (2S,4R)-1-(tert-butoxycarbonyl)-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)pyrrolidine-2-carboxylic acid 
• 1169846-35-8 (2S,4R)-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)pyrrolidine-2-carboxamide hydrochloride 

Relevant articles and documents

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection

The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis C virus infection. The discovery of 24 was enabled by employing an isolated rabbit heart model to screen for the cardiovascular (CV) liabilities (changes to HR and SNRT) that were responsible for the discontinuation of an earlier lead from this chemical series, BMS-605339 (1), from clinical trials. The structure-activity relationships (SARs) developed with respect to CV effects established that small structural changes to the P2* subsite of the molecule had a significant impact on the CV profile of a given compound. The antiviral activity, preclincial PK profile, and toxicology studies in rat and dog supported clinical development of BMS-650032 (24).

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.