95377-69-8

Basic information

• Product Name: Benzenamine, 4-(1H-imidazo[4,5-b]pyridin-2-yl)-
• Synonyms: Benzenamine, 4-(1H-imidazo[4,5-b]pyridin-2-yl)-;4-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenylamine;4-(3H-imidazo[4,5-b]pyridin-2-yl)aniline
• CAS NO: 95377-69-8
• Molecular Formula: C₁₂H₁₀N₄
• Molecular Weight: 210.2346
• Mol File: 95377-69-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenamine, 4-(1H-imidazo[4,5-b]pyridin-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-(1H-imidazo[4,5-b]pyridin-2-yl)-(95377-69-8)
• EPA Substance Registry System: Benzenamine, 4-(1H-imidazo[4,5-b]pyridin-2-yl)-(95377-69-8)

Safety Data

• Hazardous Substances Data: 95377-69-8(Hazardous Substances Data)

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 150-13-0 4-amino-benzoic acid 

Relevant articles and documents

Design and synthesis of novel imidazo[4,5-b]pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity

New imidazo[4,5-b]pyridine derivatives were designed, synthesized and screened for their anticancer activity against breast (MCF-7) and colon (HCT116) cancer cell lines. Nine compounds (I, II, IIIa, IIIb, IV, VI, VIIa, VIII, IX) showed significant activit

1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl] -urea derivatives as small molecule heparanase inhibitors

A novel class of 1-[4-(1H-benzoimidazol-2-yl)-phenyl]-3-[4-(1H- benzoimidazol-2-yl)-phenyl]-ureas are described as potent inhibitors of heparanase. Among them are 1,3-bis-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea (7a) and 1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)-phenyl]-urea (7d), which displayed good heparanase inhibitory activity (IC50 0.075-0.27 μM). Compound 7a showed good efficacy in a B16 metastasis model.