95425-24-4

Basic information

• Product Name: 1-benzyl-2-(3-nitrophenyl)-1H-benzo[d]imidazole
• Synonyms: 1-benzyl-2-(3-nitrophenyl)-1H-benzo[d]imidazole
• CAS NO: 95425-24-4
• Molecular Weight: 329.358
• Mol File: 95425-24-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzyl-2-(3-nitrophenyl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-(3-nitrophenyl)-1H-benzo[d]imidazole(95425-24-4)
• EPA Substance Registry System: 1-benzyl-2-(3-nitrophenyl)-1H-benzo[d]imidazole(95425-24-4)

Safety Data

• Hazardous Substances Data: 95425-24-4(Hazardous Substances Data)

Upstream product

• 739-88-8 1-benzyl-2-phenyl-1H-1,3-benzimidazole 
• 5822-13-9 N-benzyl-1,2-phenylenediamine 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 1082318-76-0 3-(1-benzyl-1H-benzo[d]imidazol-2-yl)aniline 
• 1568976-08-8 N-(3-(1-benzyl-1H-benzo[d]imidazol-2-yl)phenyl)-3-phenylpropanamide 

Relevant articles and documents

Benzimidazole compound with endothelial lipase inhibition effect and application of benzimidazole compound

The invention discloses a benzimidazole compound with an endothelial lipase inhibition effect and application of the benzimidazole compound, and belongs to the technical field of medicines. The benzimidazole compound has an excellent inhibition effect on endothelial lipase, can effectively treating atherosclerosis and sequelae thereof, such as coronary heart disease, and also promotes treatment onmetabolic syndrome and sequelae thereof, such as diabetes. The benzimidazole compound provided by the invention has good solubility in an aqueous medium, also has good biological activity and metabolic stability, and shows advantages in the aspect of serum stability.

BENZIMIDAZOLES FOR THE TREATMENT OF CANCER

The present invention relates to novel substituted benzimidazoles and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted benzimidazoles together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted benzimidazoles binding to the prenyl binding pocket of PDEδ have been identified as useful for the prophylaxis and treatment of cancer by the inhibition of the binding of PDEδ to K-Ras and of oncogenic Ras signalling in cells by altering its localization leading to cell death or inhibition of proliferation.