95474-20-7

Basic information

• Product Name: 4-Imidazolidinone, 3-methyl-5-(phenylmethylene)-2-thioxo-, (Z)-
• CAS NO: 95474-20-7
• Molecular Formula: C11H10N2OS
• Molecular Weight: 218.279
• Mol File: 95474-20-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Imidazolidinone, 3-methyl-5-(phenylmethylene)-2-thioxo-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Imidazolidinone, 3-methyl-5-(phenylmethylene)-2-thioxo-, (Z)-(95474-20-7)
• EPA Substance Registry System: 4-Imidazolidinone, 3-methyl-5-(phenylmethylene)-2-thioxo-, (Z)-(95474-20-7)

Safety Data

• Hazardous Substances Data: 95474-20-7(Hazardous Substances Data)

Upstream product

• 37524-22-4 2-Thioxo-4-benzyliden-thiazolidon-(5) 
• 74-89-5 methylamine 
• 100-52-7 benzaldehyde 
• 694-68-8 3-methyl-2-thioxo-imidazolidin-4-one 
• 6852-55-7 N-benzylidenepropylamine 

Relevant articles and documents

Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl) diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

The synthesis in 4 steps of new N,N′-bis(5-arylidene-4-oxo-3,5- dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro- 4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N′-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3α/β, DYRK1A, CLK1 and CLK3).