95548-68-8

Basic information

• Product Name: Pyrido[2,3-d]pyrimidine-6-carbonitrile, 7-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-phenyl-
• CAS NO: 95548-68-8
• Molecular Formula: C15H11N5O2
• Molecular Weight: 293.285
• Mol File: 95548-68-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidine-6-carbonitrile, 7-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidine-6-carbonitrile, 7-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-phenyl-(95548-68-8)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidine-6-carbonitrile, 7-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-phenyl-(95548-68-8)

Safety Data

• Hazardous Substances Data: 95548-68-8(Hazardous Substances Data)

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 123506-39-8 6-hydroxyamino-3-methyluracil 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 21236-97-5 3-methyl-6-aminouracil 

Relevant articles and documents

Arylidenemalononitriles in Heterocyclic Syntheses: a Novel Synthesis of Pyridopyrimidines

Arylidenemalononitriles react with 6-amino and 6-hydroxyamino-1,3-dimethyl- and 3-methyl-pyrimidine-2,4(1H,3H)-dione to give pyridopyrimidines in good yields.

A novel three-component one-pot synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines using microwave heating in the solid state

Microwave-assisted three-component cyclocondensation of barbituric acids 1, benzaldehyde 2 and alkyl nitriles 3 proceeds in the absence or presence of triethylamine to afford pyrano[2,3-d]pyrimidines 4 and 6-aminouracils 5 or 6-hydroxyaminouracils 6 react with 2 and 3 under identical conditions to yield pyrido[2,3-d]pyrimidines 7, all in high yields.