955949-99-2Relevant articles and documents
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives
Jarrahpour, Aliasghar,Khalili, Dariush,De Clercq, Erik,Salmi, Chanaz,Brunel, Jean Michel
, p. 1720 - 1730 (2007)
Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The chemical structures of the products were confirmed by 1H- and 13CNMR, IR and mass spectral data. The compounds were screened for antiviral activity against a panel of DNA and RNA viruses. Minimum cytotoxic and minimum virusinhibitory concentrations of these compounds were determined. Compounds 3c and 3i were the most cytotoxic in HEL cells. These newly synthesized bis-Schiff bases were also tested for their antibacterial and antifungal activities. They did not display activity against S. cerevisiae (ATCC 28383) or C. albicans (CIP 1180-79).
Synthesis of some mono- and bis-spiro-β-lactams of benzylisatin
Jarrahpour, Aliasghar,Khalili, Dariush
, p. 7140 - 7143 (2008/03/11)
Some new mono- and bis-spiro-β-lactams of benzylisatin were prepared by Staudinger's ketene-imine [2+2] cycloaddition reaction. The cycloadducts were characterized by spectral data including 1H NMR, 13C NMR, IR and mass spectra. The
