955950-58-0Relevant articles and documents
Design and synthesis of 3-arylbenzopyran based non-steroidal vitamin-D3 mimics as osteogenic agents
Ahmad, Mohd. Imran,Raghuvanshi, Dushyant Singh,Singh, Sarita,John, Aijaz A.,Prakash, Ravi,Nainawat, Kripa Shankar,Singh, Divya,Tripathi, Shubhandra,Sharma, Ashok,Gupta, Atul
, p. 2381 - 2394 (2016)
3-Arylbenzopyran based non-steroidal osteogenic agents have been explored as structural templates of estrogen and vitamin-D3. The target molecules 18a-c, 19a-c, 26a-c, 27a-c and intermediates 17a-c and 25a-c were studied for their osteogenic activity in an osteoblast differentiation assay in vitro using mouse calvarial osteoblast cells. Compounds 25c, 26b, 27b and 27c effectively increased ALP activity at 1 pM concentration compared to the untreated cells. The active compounds were devoid of inherent toxicity at 1 pM concentration in osteoblast cells. The most active compound, 27b, was studied for mineralization of osteoblast cells and expression of marker genes, viz. BMP-2, RUNX-2 & Osx, involved in osteogenesis. Molecular docking analysis performed for 27b showed its possible interactions with estrogen receptor-α and -β (ER-α and ER-β) as well as the vitamin-D receptor (VDR).
Efficient and simple synthesis of substituted 3-phenyl-7-methoxybenzopyrans as pseudo-vitamin-D3 analogs
Gupta, Atul,Ray, Suprabhat
, p. 3119 - 3126 (2008/02/12)
An efficient and simple synthesis of substituted 3-phenyl-7- methoxybenzopyrans as pseudo-vitamin-D3 analogs in good yields under mild reaction conditions is described. Copyright Taylor & Francis Group, LLC.
