95606-81-8

Basic information

• Product Name: 3'-METHYL-2-PHENYLACETOPHENONE
• Synonyms: 3'-METHYL-2-PHENYLACETOPHENONE
• CAS NO: 95606-81-8
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• Mol File: 95606-81-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 343.27°C at 760 mmHg
• Flash Point: 147.874°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 3'-METHYL-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHYL-2-PHENYLACETOPHENONE(95606-81-8)
• EPA Substance Registry System: 3'-METHYL-2-PHENYLACETOPHENONE(95606-81-8)

Safety Data

• Hazardous Substances Data: 95606-81-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14O/c1-12-6-5-9-14(10-12)15(16)11-13-7-3-2-4-8-13/h2-10H,11H2,1H3

Upstream product

• 112863-85-1 3-hydroxy-2,4-diphenyl-3-m-tolyl-butyric acid 
• 10325-82-3 m-tolyllithium 
• 114-70-5 sodium phenylacetate 
• 620-22-4 3-Methylbenzonitrile 
• 6921-34-2 benzylmagnesium chloride 
• 103-82-2 phenylacetic acid 
• 99-04-7 m-Toluic acid 
• 95607-24-2 2-Methoxy-1-phenyl-2-m-tolyl-ethanol 
• 108-88-3 toluene 
• 103-80-0 phenylacetyl chloride 
• 3728-44-7 3-(trimethylsilyl)toluene 
• 95607-22-0 2-(2-Methoxy-1-phenyl-2-m-tolyl-ethoxy)-tetrahydro-pyran 
• 95606-85-2 2-Phenyl-2-(tetrahydro-pyran-2-yloxy)-1-m-tolyl-ethanol 
• 26919-48-2 tri-m-tolylbismuth 

Downstream Products

• 546112-25-8 1-(1-(3'-methylphenyl)ethylidene)thiosemicarbazide 
• 1401421-25-7 3-(m-tolyl)cinnoline 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

1,2-Aryl Migration Induced by Amide C?N Bond-Formation: Reaction of Alkyl Aryl Ketones with Primary Amines Towards α,α-Diaryl β,γ-Unsaturated γ-Lactams

Rearrangement reactions incorporated into cascade reactions play an important role in rapidly increasing molecular complexity from readily available starting materials. Reported here is a Cu-catalyzed cascade reaction of α-(hetero)aryl-substituted alkyl (hetero)aryl ketones with primary amines that incorporates an unusual 1,2-aryl migration induced by amide C?N bond formation to produce a class of structurally novel α,α-diaryl β,γ-unsaturated γ-lactams in generally good-to-excellent yields. This cascade reaction has a broad substrate scope with respect to primary amines, allows a wide spectrum of (hetero)aryl groups to smoothly undergo 1,2-migration, and tolerates electronically diverse α-substituents on the (hetero)aryl ring of the ketones. Mechanistically, this 1,2-aryl migration may stem from the intramolecular amide C?N bond formation which induces nucleophilic migration of the aryl group from the acyl carbon center to the electrophilic carbon center that is conjugated with the resulting iminium moiety.