956486-49-0Relevant articles and documents
CRYSTALLINE ACID ADDITION SALTS AND THEIR USE AS ENZYME INHIBITORS
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Page/Page column 19, (2010/04/27)
A crystalline acid addition salt of the compound of formula (I), said salt being selected from the hydrogen sulfate, p-toluene sulfonate, naphthalene-2-sulfonate, fumarate, and ethanesulfonate salts thereof. The said salts are inhibitors of human neutrophil elastase (HNE), and thus of use in the treatment of inflammatory conditions, including those of the respiratory tract, especially when administered by inhalation for pulmonary delivey.
3,4,6,7-TETRAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDINE-2,5-DIONES AND THEIR THERAPEUTIC USE
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Page/Page column 30-31, (2009/06/27)
Compounds in which two substituted 3,4,6,7-tetrahydro-1 H-pyrrolo[3,4-d]pyrimidine-2,5- dione molecules are covalently linked via a linker radical which has contains a betaine or zwitterionic motif are inhibitors of human neutrophil elastase activity, for