956597-80-1Relevant articles and documents
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator
Zhang, Bo,Wang, Yan,Huang, Shenlong,Sun, Jiaqi,Wang, Min,Ma, Wenxiao,You, Yanbo,Wu, Ling,Hu, Jin,Song, Wei,Liu, Xudong,Li, Shengjie,Chen, Hua,Zhang, Guisheng,Zhang, Lihe,Zhou, Demin,Li, Lingjun,Zhang, Xuan
, p. 60 - 7,69 (2020/12/07)
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, which leads to worrisome side effects. Engineering CAR-T cells to be as tightly controllable as possible remains a topic of ongoing investigation. Here, we report a photoswitchable approach that uses a mediator for the at-will regulation of CAR-T cells. This mediator carries dual folate and fluorescein isothiocyanate moieties tethered by an ortho-nitrobenzyl ester photocleavable linker. CAR-T cells were shown to be highly cytotoxic to targeted cells only in the presence of the mediator and acted in a dose-dependent manner. The toxicity of CAR-T cells can be rapidly terminated by cleavage of the mediator, and the effects of CAR-T cells can be activated again by resupplementation with the mediator without compromising tumor therapy. The approach described here provides a direction for enhancing the controllability of CAR-T cells and can likely be applied in other immunotherapies.CAR-T is a powerful technology for cancer therapy, but is largely limited by inherent controllability issues. Zhang et al. developed an accurate controllable approach based on the bond-cleavage chemistry combined with universal anti-FITC CAR-T cells, allowing the regulation of CAR-T cells in a switchable manner.
Bis-Organosilicon based receptor for detection of Hg2+ ions: Low detection limit and excellent selectivity
Chowdhary, Kavita,Mohit,Satija, Pinky,Sharma, Geetika,Shilpy,Singh, Akshpreet,Singh, Gurjaspreet,Singh, Jandeep,Singh, Jasbhinder
, (2020/08/03)
Mercury Contamination represents a major environmental and health concern for which new eco-friendly solutions are desired. Azide–alkyne cycloaddition and Claisen Schmidt reaction were attempted to trigger a flavanone based bis-siloxyl hybrid materials. T
4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation
Kumar, Sumit,Saini, Anu,Gut, Jiri,Rosenthal, Philip J.,Raj, Raghu,Kumar, Vipan
, p. 993 - 1001 (2017/08/02)
1H-1,2,3-triazole linked 4-aminoquinoline-chalcone/-N-acetylpyrazoline conjugates were synthesized and evaluated against cultured chloroquine (CQ) resistant strain. Antiplasmodial activities of the synthesized conjugates revealed dependence of activity on