95674-69-4

Basic information

• Product Name: diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate
• Synonyms: diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate
• CAS NO: 95674-69-4
• Molecular Weight: 494.55
• Mol File: 95674-69-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate(95674-69-4)
• EPA Substance Registry System: diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethyl>benzoyl>-L-glutamate(95674-69-4)

Safety Data

• Hazardous Substances Data: 95674-69-4(Hazardous Substances Data)

Upstream product

• 497-19-8 sodium carbonate 
• 99-94-5 p-Toluic acid 
• 106200-43-5 2-cyano-4-p-carbomethoxyphenethyl-5-piperidino-2,4-pentadienonitrile 
• 106200-44-6 2-amino-3-cyano-5-p-carbomethoxyphenethylpyridine 
• 106200-42-4 piperidine enamine of 4-p-carbomethoxyphenylbutyraldehyde 
• 155405-82-6 1-methoxy-4-p-carbomethoxyphenyl-1-butene 
• 272779-19-8 4-((E)-4-Methoxy-but-3-enyl)-benzoic acid 
• 106200-41-3 4-(4-carbomethoxyphenyl)butanal 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 70583-34-5 [4-((S)-1,3-Bis-ethoxycarbonyl-propylcarbamoyl)-benzyl]-triphenyl-phosphonium; bromide 
• 95674-65-0 2,4-diamino-6-<4-(tert-butoxycarbonyl)styryl>-5-deazapteridine 
• 95674-66-1 2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine 
• 80360-04-9 2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine 
• 95674-67-2 diethyl N-<4-<2-(2,4-diamino-5-deaza-6-pteridyl)ethenyl>benzoyl>-L-glutamate 

Downstream Products

• 95674-53-6 5,10-dideazaaminopterin 

Relevant articles and documents

Pyrido(2,3-d)pyrimidine derivatives

2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[1-(pyrido[2,3-d]pyrimidin-6-yl)alk-2-yl]-benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid.

Synthesis of the Antileucemic Agents 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin

Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described.These compounds exhibit significant in vivo activity against L1210 leukemia that comparable to that observed with meth