956822-01-8Relevant articles and documents
Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR)
Hubbard, Robert D.,Bamaung, Nwe Y.,Palazzo, Fabio,Zhang, Qian,Kovar, Peter,Osterling, Donald J.,Hu, Xiaoming,Wilsbacher, Julie L.,Johnson, Eric F.,Bouska, Jennifer,Wang, Jieyi,Bell, Randy L.,Davidsen, Steven K.,Sheppard, George S.
, p. 5406 - 5409 (2007)
A high throughput screen of Abbott's compound repository revealed that the pyrazolo[3,4-d]pyrimidine class of kinase inhibitors possessed moderate potency for IGF-IR, a promising target for cancer chemotherapy. The synthesis and subsequent optimization of this class of compounds led to the discovery of 14, a compound that possesses in vivo IGF-IR inhibitory activity.
