957207-06-6Relevant articles and documents
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H-benzo[ b][1,4]oxazin-6-yl Moiety
Ikeda, Shuhei,Sugiyama, Hideyuki,Tokuhara, Hidekazu,Murakami, Masataka,Nakamura, Minoru,Oguro, Yuya,Aida, Jumpei,Morishita, Nao,Sogabe, Satoshi,Dougan, Douglas R.,Gay, Sean C.,Qin, Ling,Arimura, Naoto,Takahashi, Yasuko,Sasaki, Masako,Kamada, Yusuke,Aoyama, Kazunobu,Kimoto, Kouya,Kamata, Makoto
, p. 11014 - 11044 (2021/08/24)
The therapeutic potential of monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases has attracted attention worldwide. However, the availability of reversible-type inhibitor is still limited to clarify the pharmacological eff
HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE
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Page/Page column 249-250, (2009/02/10)
To provide a novel compound which has S1P receptor agonistic activity, exhibits excellent immunosuppressing effect, gives less adverse side effects, and can be orally administered. The invention provides a compound represented by general formula (I) (wherein A is a single bond, -O-, or - CH2-; R1 represents a hydrogen atom or a C1-C6 alkyl group, and V represents any one group selected from among the following groups (1) to (3) : (1) -G1-, (2) -G2-N(R2) -G3-, and (3) a group represented by formula 2, wherein each of Z1 and Z2 represents a hydrogen atom or a C1-C6 alkyl group, Z3 represents a hydrogen or the like, Q represents -CH2-O- or the like, and Y represents a group represented by foumula 3, a salt thereof, or a solvate thereof.