957207-09-9Relevant articles and documents
Intermediate of siponimod and synthesis method thereof
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Paragraph 0071-0075, (2021/05/05)
The invention relates to a novel intermediate compound (a compound as shown in a formula 2A) of siponimod, a synthesis method of the novel intermediate compound, and a method for synthesizing siponimod by adopting the compound as shown in the formula 2A. Specifically, 3-trifluoromethyl-4-halogenated benzoic acid or 3-trifluoromethyl-4-halogenated toluene is taken as an initial raw material and is subjected to reduction, bromination, coupling, substitution and reduction to obtain a compound as shown in a formula 2A, and R is Boc or Ac.
SELECTIVE FLUORESCENT PROBE FOR ALDEHYDE DEHYDROGENASE
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, (2020/07/14)
High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
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Paragraph 0386-0387, (2018/10/21)
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).