95751-30-7 Usage
Description
Charybdotoxin is a small protein toxin that is derived from the venom of the scorpion Leiurus quinquestriatus. It is a potent inhibitor of certain types of potassium channels, particularly those of the Kv1.3 variety, which are involved in a variety of physiological processes. Charybdotoxin has a molecular weight of approximately 4 kDa and consists of 37 amino acid residues. Its structure is stabilized by four disulfide bonds, which give it high stability and resistance to denaturation.
Uses
Used in Pharmaceutical Industry:
Charybdotoxin is used as a research tool for studying the structure and function of potassium channels, particularly the Kv1.3 channels. It helps scientists understand the role of these channels in various diseases and develop potential therapeutic agents targeting them.
Used in Electrophysiological Studies:
Charybdotoxin is used as a calcium channel blocker in electrophysiological studies. It helps researchers investigate the role of calcium channels in cellular processes and their involvement in various diseases.
Used in Inhibition of Endothelium-Derived Hyperpolarizing Factor Responses:
Charybdotoxin is used to inhibit endothelium-derived hyperpolarizing factor (EDHF) responses. This helps researchers study the mechanisms of vasodilation and the role of EDHF in cardiovascular health.
Used as a Transport Inhibitor:
Charybdotoxin is used as a transport inhibitor in various experimental setups. It can help researchers understand the transport mechanisms of ions and molecules across cell membranes and their implications in different physiological and pathological conditions.
Biochem/physiol Actions
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
Check Digit Verification of cas no
The CAS Registry Mumber 95751-30-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,7,5 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 95751-30:
(7*9)+(6*5)+(5*7)+(4*5)+(3*1)+(2*3)+(1*0)=157
157 % 10 = 7
So 95751-30-7 is a valid CAS Registry Number.