95772-54-6

Basic information

• Product Name: Ethacrynic Acid IMpurity B
• Synonyms: 2-[2,3-Dichloro-4-[2-(hydroxyMethyl)-1-oxobutyl]phenoxy]acetic Acid;2-DesMethylene-2-chloroMethyl Ethacrynic Acid;Ethacrynic Acid IMpurity B;Etacrynic Acid EP Impurity B
• CAS NO: 95772-54-6
• Molecular Formula: C13H12Cl2O4
• Molecular Weight: 303.13798
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 95772-54-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Ethacrynic Acid IMpurity B(CAS DataBase Reference)
• NIST Chemistry Reference: Ethacrynic Acid IMpurity B(95772-54-6)
• EPA Substance Registry System: Ethacrynic Acid IMpurity B(95772-54-6)

Safety Data

• Hazardous Substances Data: 95772-54-6(Hazardous Substances Data)

Usage

Uses

2-Desmethylene-2-chloromethyl Ethacrynic Acid is an impurity of Ethacrynic Acid (E676000).

Upstream product

• 58-54-8 ethacrynic acid 

Relevant articles and documents

Liquid chromatographic analysis of ethacrynic acid and degradation products in pharmaceutical systems

An accurate, reproducible, and specific reversed-phase high-performance liquid chromatographic (HPLC) system was developed for the determination of ethacrynic acid and its degradation products. The method was used in stability studies of the drug in the solid state, in solution, and in dosage forms. Three degradation products were isolated by preparative chromatography and identified by several techniques, principally NMR and MS. TLC R(f) and HPLC response factors are quoted. A degradation scheme consistent with the observed stability profiles is proposed.