958-74-7

Basic information

• Product Name: 3-METHYLTHYMIDINE
• Synonyms: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethyl-pyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethylpyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,5-dimethyl-pyrimidine-2,4-quinone;N3-METHYLTHYMIDINE;methylthymidine;3-METHYLTHYMIDINE
• CAS NO: 958-74-7
• Molecular Formula: C₁₁H₁₆N₂O₅
• Molecular Weight: 256.26
• Mol File: 958-74-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 457.7°C at 760 mmHg
• Flash Point: 230.6°C
• Appearance: /
• Density: 1.409g/cm³
• Vapor Pressure: 2.65E-10mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: ?20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-METHYLTHYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLTHYMIDINE(958-74-7)
• EPA Substance Registry System: 3-METHYLTHYMIDINE(958-74-7)

Safety Data

• Hazardous Substances Data: 958-74-7(Hazardous Substances Data)

Usage

General Description

3-Methylthymidine is a modified nucleoside that contains a methyl group attached to the 3' position of the thymidine base. It is commonly found in transfer RNA and is involved in regulating the stability and function of tRNAs. The methylation of thymidine is an important chemical modification that can impact the overall function and expression of genes. 3-Methylthymidine is also used as a biomarker for oxidative stress and DNA damage as it is produced during these processes. Studying 3-methylthymidine can provide insights into the molecular mechanisms of various diseases and conditions, making it an important chemical for both basic research and clinical applications.

InChI:InChI=1/C11H16N2O5/c1-6-4-13(11(17)12(2)10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,3,5H2,1-2H3/t7-,8+,9+/m0/s1

Upstream product

• 18412-81-2 dodecyl-dimethylsulphonium iodide 
• 50-89-5 (+/-)-thymidine 
• 64969-77-3 hexadecyl-dimethylsulphonium iodide 

Downstream Products

• 99268-60-7 3',5'-bis(O-pentafluorobenzyl)-3-methylthymidine 
• 163295-92-9 3'-O-(tert-Butyldiphenylsilyl)-N³-methyl-4-thiothymidine 
• 163295-91-8 5'-O-(Dimethoxytrityl)-N³-methyl-4-thiothymidine 
• 163436-89-3 (Sp)-5'-O-(tert-Butyldiphenylsilyl)thymidylyl-(3'->5')-3'-O-(ter-butyldiphenylsilyl)-N³-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 163295-94-1 (Rp)-5'-O-(tert-Butyldiphenylsilyl)thymidylyl-(3'->5')-3'-O-(ter-butyldiphenylsilyl)-N³-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 163436-90-6 (Rp)-Thymidylyl-(3'->5')-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 162760-02-3 (Sp)-Thymidylyl-(3'->5')-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 1585199-20-7 5′-O-benzoyl-N³-methyl-3′-O-trityl-thymidine 
• 1585199-21-8 N³-methyl-3′-O-trityl-thymidine 
• 65150-68-7 N³-methyl-3′,5′-di-O-methyl-thymidine 
• 122902-47-0 N³-methyl-5′-O-trityl-thymidine 
• 1585199-22-9 N³-methyl-3′,5′-di-O-trityl-thymidine 
• 1585199-19-4 5′-O-benzoyl-N³-methyl-thymidine 
• 1585199-25-2 3′,5′-di-O-benzyl-N³-methyl-thymidine 

Relevant articles and documents

Micellar Methylating Agents: (Long-chain-alkyl)dimethylsulphonium Iodides

Dodecyl-, hexadecyl-, and octadecyl-dimethylsulphonium iodide were found to methylate efficiently various nucleosides, hydroxy aromatic compounds, and thiols at pH 8-11 and 50 - 70 deg C.The optimum conditions and the mechanism of the reaction are discussed briefly in relation to the micellar reaction characteristics.