958653-26-4Relevant articles and documents
Aryl-4-ethynyl-isoxazole derivatives
-
Page/Page column 8, (2008/06/13)
The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula I wherein R1 to R5 are as described in the specification and pharmaceutically acceptable salt thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites, being useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.