958752-88-0Relevant articles and documents
Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis
Tao, Ye,Gilbertson, Scott R.
, p. 11292 - 11295 (2018)
The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99?:?1 d.r.).