959020-16-7

Basic information

• Product Name: 2-chloro-4-(iso-propyl)pyridine
• CAS NO: 959020-16-7
• Molecular Weight: 155.627
• Mol File: 959020-16-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 211.4±20.0 °C(Predicted)
• Density: 1.075±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-chloro-4-(iso-propyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(iso-propyl)pyridine(959020-16-7)
• EPA Substance Registry System: 2-chloro-4-(iso-propyl)pyridine(959020-16-7)

Safety Data

• Hazardous Substances Data: 959020-16-7(Hazardous Substances Data)

Usage

Description

2-Chloro-4-(1-methylethyl)pyridine, also known as 2-chloro-4-(iso-propyl)pyridine, is an organic compound that serves as a building block for the synthesis of various compounds with therapeutic properties.

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-(iso-propyl)pyridine is used as a building block for the synthesis of various compounds with therapeutic properties, contributing to the development of new drugs and treatments for various medical conditions. Its unique chemical structure allows for the creation of diverse molecules with potential medicinal applications.

Upstream product

• 75-30-9 2-iodo-propane 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 807329-97-1 TurboGrignard 
• 109-09-1 2-chloropyridine 
• 696-30-0 4-s-propylpyridine 
• 153034-86-7 2-chloro-4-iodopyridine 
• 17144-80-8 triisopropyl indium 

Downstream Products

• 1047650-71-4 4-(1-methylethyl)-2-[[[1-methyl-5-(2,2,2-trifluoroethoxy)-3-trifluoromethyl-1H-pyrazol-4-yl]methyl]thio]pyridine 1-oxide 

Relevant articles and documents

Radical chain monoalkylation of pyridines

The monoalkylation of N-methoxypyridinium salts with alkyl radicals generated from alkenes (via hydroboration with catecholborane), alkyl iodides (via iodine atom transfer) and xanthates is reported. The reaction proceeds under neutral conditions since no acid is needed to activate the heterocycle and no external oxidant is required. A rate constant for the addition of a primary radical to N-methoxylepidinium >107 M-1 s-1 was experimentally determined. This rate constant is more than one order of magnitude larger than the one measured for the addition of primary alkyl radicals to protonated lepidine demonstrating the remarkable reactivity of methoxypyridinium salts towards radicals. The reaction has been used for the preparation of unique pyridinylated terpenoids and was extended to a three-component carbopyridinylation of electron-rich alkenes including enol esters, enol ethers and enamides.

Organometallic compound and organic light-emitting device including the same

Organic metal compound and said organometallic compounds is disclosure is an organic light emitting device. (by machine translation)

Transition-metal-free BF3-mediated oxidative and non-oxidative cross-coupling of pyridines

We report a BF3-mediated direct alkynylation of pyridines at C(2) by using a variety of alkynyllithium reagents (oxidative cross-coupling). Moreover, we have developed a novel transition-metal-free cross-coupling method between alkylmagnesium reagents and 4-substituted pyridines, such as isonicotinonitrile and 4-chloropyridine, by employing BF3· OEt2 as a promoter. The combination of these methods enabled us to efficiently prepare a range of di-, tri-, and tetrasubstituted pyridines. Oxidative or non-oxidative - That is the question! Pyridines bearing a substituent at position 4 readily undergo a BF3-mediated oxidative coupling at position 2 with a wide range of alkynyllithium compounds. In contrast, 4-cyano- or 4-chloropyridines undergo a novel BF3-mediated cross-coupling at position 4 with alkylmagnesium reagents. The combination of the two transition-metal-free procedures allows the preparation of a broad range of pyridines.