959694-62-3

Basic information

• Product Name: methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate
• Synonyms: methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate
• CAS NO: 959694-62-3
• Molecular Weight: 223.272
• Mol File: 959694-62-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate(959694-62-3)
• EPA Substance Registry System: methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate(959694-62-3)

Safety Data

• Hazardous Substances Data: 959694-62-3(Hazardous Substances Data)

Upstream product

• 871842-89-6 (R)-1-carboxy-1-(4-methoxyphenyl)ethyl ammonium hydrochloride 
• 959694-61-2 methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate 
• 74-88-4 methyl iodide 
• 959694-59-8 methyl (R)-2-amino-2-(4-methoxyphenyl)propionate 
• 959694-60-1 (R)-2-acetylamino-2-(4-methoxyphenyl)propanoic acid 
• 197643-97-3 C₁₂H₁₅NO₄ 
• 22927-78-2 5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione 

Downstream Products

• 959691-72-6 (R)-1-(3,4-dichlorophenyl)-3,4-dimethyl-4-(4-methoxyphenyl)-2-thioxoimidazolidin-5-one 
• 959691-78-2 (R)-1-(3,4-dichlorophenyl)-3,4-dimethyl-4-(4-hydroxyphenyl)-2-thioxoimidazolidin-5-one 

Relevant articles and documents

Discovery of diarylhydantoins as new selective androgen receptor modulators

A novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens. Several 4-(4-hydroxyphenyl)-N-arylhydantoins displayed partial agonism with nanomolar in vitro potency in transactivation experiments using androgen receptor (AR) transfected cells. In a standard castrated male rat model, several compounds showed good anabolic activity on levator ani muscle, dissociated from the androgenic activity on ventral prostate, after oral dosing at 30 mg/kg. (+)-4-[3,4-Dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl] -2-(trifluoromethyl)benzonitrile ((+)-11b) displayed anabolic potency with a strong dissociation between levator ani muscle and ventral prostate (A 50 = 0.5 mg/kg vs 70 mg/kg). The binding modes of two compounds, including (+)-11b, within the AR ligand-binding domain have been studied by cocrystallization experiments using a coactivator-like peptide. Both compounds bound to the same site, and the overall structures of the AR were very similar.