96013-78-4

Basic information

• Product Name: Phenol, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-
• Synonyms: 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenol;Phenol,3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl];3-(tert-butyl-dimethyl-silanyloxymethyl)-phenol
• CAS NO: 96013-78-4
• Molecular Formula: C13H22O2Si
• Molecular Weight: 238.402
• Mol File: 96013-78-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Phenol, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(96013-78-4)
• EPA Substance Registry System: Phenol, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-(96013-78-4)

Safety Data

• Hazardous Substances Data: 96013-78-4(Hazardous Substances Data)

Upstream product

• 620-24-6 3-Hydroxybenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 41879-37-2 t-butyldimethylsilyl amine 
• 96013-69-3 tert-butyl((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)dimethylsilane 

Downstream Products

• 53172-91-1 (benzyloxy)(tert-butyl)dimethylsilane 
• 1100767-49-4 1-{3-bromo-4-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenoxy]-phenyl}-ethanone 
• 654069-08-6 3-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl(2Z)-4-hydroxy-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-enyl carbonate 

Relevant articles and documents

Toward the Total Synthesis of Scabrosins: Synthesis of a Desulfur-scabrosin Skeleton and Its Stereoisomers

The enantioselective synthesis of a desulfur-scabrosin skeleton was reported. The synthesis began from 3-(hydroxymethyl)phenol, and key steps include asymmetric nucleophilic epoxidation, a Mitsunobu reaction using a sulfonamide as the nucleophile, the con

TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE

The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity

Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator that specifically activates membrane proteins of the P2Y and its related families of G protein-coupled receptors (GPCR), GPR34 (LPS1), P2Y10 (LPS2), and GPR174 (LPS3). Here, in order to increase potency and receptor selectivity, we designed and synthesized LysoPS analogues containing the conformational constraints of the glycerol moiety. These reduced structural flexibility by fixation of the glycerol framework of LysoPS using a 2-hydroxymethyl-3-hydroxytetrahydropyran skeleton, and related structures identified compounds which exhibited high potency and selectivity for activation of GPR34 or P2Y10. Morphing of the structural shape of the 2-hydroxymethyl-3-hydroxytetrahydropyran skeleton into a planar benzene ring enhanced the P2Y10 activation potentcy rather than the GPR34 activation.