96027-74-6 Usage
Description
Desethyl Amiodarone Hydrochloride, also known as Amiodarone EP Impurity B, is the primary active metabolite of Amiodarone, a non-selective ion channel blocker. It is used as a Certified Spiking Solution for therapeutic drug monitoring analyses by HPLC or LCMS. Amiodarone is an antiarrhythmic agent marketed under various brand names such as Pacerone, Cordarone, Aratac, and Atlansil, and is monitored by clinical labs to ensure patients remain within the drug's therapeutic range.
Uses
Used in Pharmaceutical Industry:
Desethyl Amiodarone Hydrochloride is used as a reference standard for the development and validation of analytical methods in the pharmaceutical industry. It helps in ensuring the quality, purity, and potency of Amiodarone-containing products.
Used in Clinical Laboratories:
Desethyl Amiodarone Hydrochloride is used as a spiking solution in therapeutic drug monitoring analyses by HPLC or LCMS. It aids in the accurate measurement of Amiodarone levels in patients, helping healthcare professionals to monitor and adjust dosages to maintain the drug's therapeutic range.
Used in Research and Development:
Desethyl Amiodarone Hydrochloride is used as a research tool in the study of ion channel blockers and their effects on cardiac arrhythmias. It contributes to the understanding of the mechanisms of action and potential applications of Amiodarone and its metabolites in the treatment of various cardiac conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 96027-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,0,2 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 96027-74:
(7*9)+(6*6)+(5*0)+(4*2)+(3*7)+(2*7)+(1*4)=146
146 % 10 = 6
So 96027-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H
96027-74-6Relevant articles and documents
Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives
Waldhauser, Katri Maria,Toeroek, Michael,Ha, Huy-Riem,Thomet, Urs,Konrad, Daniel,Brecht, Karin,Follath, Ferenc,Kraehenbuehl, Stephan
, p. 1413 - 1423 (2006)
The aim of this work was to compare hepatocellular toxicity and pharmacological activity of amiodarone (2-n-butyl-3-[3,5 diiodo-4- diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N-diethyl) and of eight amiodarone derivatives. Three amiodarone metabolites
Pharmaceutical and veterinary compositions for the treatment of ischemic cardiac disorders
-
, (2008/06/13)
Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: STR1 or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X1 and X2 represent hydrogen or iodine with the proviso that when R represents diethylamino X1 and X2 are different. These compositions are useful for the treatment of ischemic cardiac disorders.
