960289-03-6

Basic information

• Product Name: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE
• Synonyms: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE;2-Bromo-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;2-broMo-4H,5H,6H,7H-thieno[2,3-c]pyridin-7-one;2-broMo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one;2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one,tech;2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)
• CAS NO: 960289-03-6
• Molecular Formula: C₇H₆BrNOS
• Molecular Weight: 232.09764
• Mol File: 960289-03-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 471.848°C at 760 mmHg
• Flash Point: 239.165°C
• Appearance: /
• Density: 1.726g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 13.97±0.20(Predicted)
• CAS DataBase Reference: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(960289-03-6)
• EPA Substance Registry System: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE(960289-03-6)

Safety Data

• Hazardous Substances Data: 960289-03-6(Hazardous Substances Data)

Usage

Description

2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one is a chemical compound that serves as an intermediate in the synthesis of thieno[2,3-c]pyridine derivatives. These derivatives are known for their potential as MCH (melanin-concentrating hormone) receptor antagonists, which can be utilized in various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one is used as a key intermediate in the preparation of thieno[2,3-c]pyridine derivatives. These derivatives are employed as MCH receptor antagonists for their potential role in treating various disorders related to the MCH receptor, such as obesity, depression, and anxiety. The antagonistic action of these derivatives on the MCH receptor can help regulate the associated physiological processes and provide therapeutic benefits.

InChI:InChI=1/C7H6BrNOS/c8-5-3-4-1-2-9-7(10)6(4)11-5/h3H,1-2H2,(H,9,10)

Upstream product

• 14470-51-0 5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one 
• 16378-06-6 3-(3-thienyl)propanoic acid 
• 5650-52-2 4,5-dihydro-6H-cyclopenta[b]thiophen-6-one 
• 13781-53-8 (thiophen-3-yl)acetonitrile 
• 960289-02-5 (2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester 
• 34843-84-0 2-(thiophen-3-yl)ethan-1-amine hydrochloride 

Downstream Products

• 960289-08-1 2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960402-40-8 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one 
• 960400-65-1 6-(4-hydroxy-3-methoxy-phenyl)-2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960401-13-2 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester 
• 960401-15-4 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid 
• 960402-73-7 (+/-)-pyrrolidine-3-carboxylic acid {4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenyl}-amide 
• 960401-12-1 trifluoromethanesulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester 
• 960400-59-3 toluene-4-sulfonic acid 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-phenyl ester 
• 960402-65-7 (+/-)-3-{4-[2-(4-chloro-phenyl)-7-oxo-7H-thieno[2,3-c]pyridin-6-yl]-phenylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 960402-67-9 (+/-)-2-(4-chloro-phenyl)-6-[3-methoxy-4-(pyrrolidine-3-carbonyl)-phenyl]-6H-thieno[2,3-c]pyridin-7-one trifluoroacetic acid 

Relevant articles and documents

MST1 KINASE INHIBITORS AND METHODS OF THEIR USE

Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.