96090-12-9

Basic information

• Product Name: Benzene, 1-bromo-4-(3-bromo-1-propenyl)-
• CAS NO: 96090-12-9
• Molecular Formula: C9H8Br2
• Molecular Weight: 275.971
• Mol File: 96090-12-9.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(3-bromo-1-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(3-bromo-1-propenyl)-(96090-12-9)
• EPA Substance Registry System: Benzene, 1-bromo-4-(3-bromo-1-propenyl)-(96090-12-9)

Safety Data

• Hazardous Substances Data: 96090-12-9(Hazardous Substances Data)

Upstream product

• 58824-56-9 1-(p-bromophenyl)prop-2-en-1-ol 
• 1200-07-3 trans-4-bromocinnamic acid 
• 49678-04-8 4-bromocinnamaldeyde 
• 1826-67-1 vinyl magnesium bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 105515-33-1 3-(4-bromophenyl)prop-2-en-1-ol 
• 24393-53-1 ethyl 4-bromocinnamate 
• 1200-07-3 3-(4-bromophenyl)acrylic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 49678-04-8 trans-4-bromocinnamaldehyde 
• 122058-30-4 p-methylcinnamyl alcohol 
• 97585-04-1 ethyl (E)-3-(4-methylphenyl)acrylate 
• 104-87-0 4-methyl-benzaldehyde 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 111678-30-9 3-[(E)-3-(4-Bromo-phenyl)-allyl]-quinoline 
• 111678-31-0 3-[1-(4-Bromo-phenyl)-allyl]-quinoline 
• 96090-14-1 3-[1-(4-Bromo-phenyl)-allyl]-pyridine 
• 1277184-91-4 (3R,4aS,9S,9aR)-9-(4-bromophenyl)-7-nitro-3-propyl-1,2,3,4,4a,9,9a,10-octahydroacridine-2,2(1H)-dicarbonitrile 
• 1277185-06-4 (E)-2-(3-(4-bromophenyl)allyl)malononitrile 
• 1311160-77-6 (E)-6-(4-bromophenyl)hex-5-enal 
• 1311160-90-3 (3R,3aS,9R,9aS)-9-(4-bromophenyl)-3-((S)-2-nitro-1-phenylethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinoline 
• 1311160-91-4 (3R,3aS,9R,9aS)-ethyl 9-(4-bromophenyl)-3-((S)-2-nitro-1-phenylethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinoline-7-carboxylate 
• 1581720-65-1 (E)-1-(3-(4-bromophenyl)allyl)-1-(2-(4-nitrophenoxy)-2-oxoethyl)piperidin-1-ium bromide 
• 1581720-44-6 (E)-3-(4-bromophenyl)-N,N-dimethyl-N-(2-(4-nitrophenoxy)-2-oxoethyl)prop-2-en-1-aminium bromide 
• 1581720-25-3 (2S,3S)-N-benzyl-3-(4-bromophenyl)-2-(piperidin-1-yl)pent-4-enamide 
• 1581720-29-7 (2S,3S)-N-benzyl-3-(4-bromophenyl)-2-(dimethylamino)pent-4-enamide 
• 1613244-45-3 (S,E)-1-(3-(4-bromophenyl)allyl)-1-(1-(3,4-dihydroquinolin-1(2H)-yl)-1-oxopropan-2-yl)piperidin-1-ium bromide 

Relevant articles and documents

Gold-Catalyzed Formal Hexadehydro-Diels-Alder/Carboalkoxylation Reaction Cascades

A dual gold-catalyzed hexadehydro-Diels-Alder/carboalkoxylation cascade reaction is reported. In this transformation, the gold catalyst participated in the hexadehydro-Diels-Alder step, switching the mechanism from a radical type to a cationic one, and then the catalyst activated the resulting aryne to form an ortho-Au phenyl cation species, which underwent a carboalkoxylation rearrangement rather than the expected aryne-ene reaction.

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

METHOD FOR SYNTHESIS OF DIAZABICYCLO[6.2.0]DECANE RELATED COMPOUNDS

A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the