96145-98-1Relevant articles and documents
In vitro metabolism of the new insecticide flupyrazofos by rat liver microsomes
Lee,Jeong,Kim,Kim,Lee,Kang,Roh
, p. 423 - 429 (1997)
1. The in vitro metabolism of the new insecticide flupyrazofos was studied using rat liver microsomes. Two metabolites were produced and identified as O,O-diethyl O-(1-phenyl-3-trifluoromethyl-5-pyrazoyl) phosphoric acid ester (flupyrazofos oxon) and 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (PTMHP) based on UV and mass spectral analysis. 2. Cytochrome P450 oxidatively converted flupyrazofos to flupyrazofos oxon, a major metabolite and phenobarbital-induced microsomes increased this desulphuration by 8-fold. 3. Flupyrazofos oxon was converted to PTMHP with a half-life of 47.8 min by chemical hydrolysis and this conversion also proceeded non-enzymatically under our microsomal incubation conditions.
F(1H-Pyrazol-4-yl)methylene-Hydrazide derivatives: Synthesis and antimicrobial activity
Bhavanarushi, Sangepu,Luo, Zhi-Bin,Bharath, Gandu,Rani, JettiVatsala,Khan, Imran,Xu, Yin,Liu, Bin,Xie, Jimin
, p. 751 - 760 (2019/11/22)
This paper investigates the seismic and collapse performance of shape memory alloy (SMA) braced steel frame structures considering the effects of various brace design parameters and ultimate state of SMAs. An SMA braced steel frame building is designed to
Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs
Gao, Jinxu,Mfuh, Adelphe,Amako, Yuka,Woo, Christina M.
supporting information, p. 4259 - 4268 (2018/04/05)
Many therapeutics elicit cell-type specific polypharmacology that is executed by a network of molecular recognition events between a small molecule and the whole proteome. However, measurement of the structures that underpin the molecular associations bet