962-08-3

Basic information

• Product Name: N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE
• Synonyms: N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE;N-(4-Chlorophenyl)-b-oxo-benzenepropanamide
• CAS NO: 962-08-3
• Molecular Formula: C₁₅H₁₂ClNO₂
• Molecular Weight: 273.718
• Mol File: 962-08-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE(962-08-3)
• EPA Substance Registry System: N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE(962-08-3)

Safety Data

• Hazardous Substances Data: 962-08-3(Hazardous Substances Data)

Usage

General Description

N-(4-chlorophenyl)-beta-oxo-benzenepropanamide, also known as 4'-chloroacetophenone, is a chemical compound with the molecular formula C10H9ClO. It is an organic compound commonly used as an intermediate for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a white crystalline powder that is insoluble in water but soluble in organic solvents. N-(4-CHLOROPHENYL)-BETA-OXO-BENZENEPROPANAMIDE is utilized in the production of various drugs and is also used in the synthesis of fragrances and flavorings. Due to its versatile applications, N-(4-chlorophenyl)-beta-oxo-benzenepropanamide plays a significant role in the chemical industry.

Upstream product

• 13165-68-9 N-(4-chloro-phenyl)-sulfur imide oxide 
• 55991-67-8 5-phenylfuran-2,3-dione 
• 104-12-1 p-chlorphenylisocyanate 
• 98-86-2 acetophenone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 106-47-8 4-chloro-aniline 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 
• 10507-69-4 4-methoxybenzohydroxamic acid 

Downstream Products

• 30169-33-6 6-chloro-4-phenyl-2-quinolinone 
• 88078-12-0 (3aR,9aS)-3-Benzoyl-1-(4-chloro-phenyl)-4-methyl-1,3,3a,4,9,9a-hexahydro-pyrrolo[2,3-b]quinoxalin-2-one 
• 88078-13-1 (3aR,9aS)-3-Benzoyl-1-(4-chloro-phenyl)-4-ethyl-1,3,3a,4,9,9a-hexahydro-pyrrolo[2,3-b]quinoxalin-2-one 
• 126081-41-2 2-{2-[3-(4-Chloro-phenylamino)-5-phenyl-pyrazol-1-yl]-2-oxo-ethyl}-4-phenyl-2H-phthalazin-1-one 
• 98-86-2 acetophenone 
• 1219-99-4 N,N'-bis(4-chlorophenyl)urea 
• 128692-09-1 3-Benzoyl-1-(4-chloro-phenyl)-2,6-dihydroxy-1H-pyridin-4-one 
• 10352-30-4 2,6-dichloro-4-phenylquinoline 
• 30169-33-6 6-Chlor-1,2-dihydro-4-phenylchinolin-2-on 
• 121819-45-2 C₁₇H₁₀ClNO₄ 
• 1449570-48-2 N-(4-chlorophenyl)-5-((E)-hex-1-enyl)-2-methylfuran-3-carboxamide 
• 31640-43-4 N-(4-chlorophenyl)-2,3-dioxo-3-phenylpropanamide 

Relevant articles and documents

1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: An Efficient Synthesis of 2-Quinolinones via β-Keto Amides

Under thermal conditions, 1,4,2-dioxazol-5-ones are known to undergo decarboxylation followed by Lossen's rearrangement to yield isocyanates. Described herein is the in situ trapping of the resulting isocyanates with carbon nucleophiles to synthesize β-keto amides. Furthermore, a general and mild method for the conversion of the resulting β-keto amides into quinolin-2-ones is reported.

A NEW SYNTHESIS OF β-KETO AMIDES VIA REACTION OF KETONE LIZHIUM ENOLATES WITH ISOCYANATES

A series of β-ketoamides was prepared by a convenient new method involving addition of various isocyanates to lithium enolates of acetophenone propiophenone and pinacolone.