96255-83-3Relevant articles and documents
A SIMPLE EFFICIENT SYNTHESIS OF KEY SYNTHETIC INTERMEDIATES OF 4-DEMETHOXYANTHRACYCLINONES, (+/-)- AND (R)-(-)-7-DEOXY-4-DEMETHOXYDAUNOMYCINONE
Suzuki, Michiyo,Matsumoto, Teruyo,Abe, Rumiko,Kimura, Yoshikazu,Terashima, Shiro
, p. 57 - 60 (1985)
(+/-)-2,5,12-Trihydroxy-1,2,3,4-tetrahydronaphthacene-6,11-di-one-2-carboxylic acid was found to readily afford the racemic title compound by successive treatments with N,N'-carbonyldiimidazole and methylmagnesium bromide in the presence of trimethylsilyl triflate.The same reaction scheme could also furnish the optically pure title compound from the (R)-carboxylic acid produced by the optical resolution.