96286-08-7 Usage
Description
2-[1-(Methylamino)ethyl]indole is a yellow crystalline solid that serves as a valuable intermediate in the synthesis of pharmaceutical actives, intermediates, and fine chemicals.
Uses
Used in Pharmaceutical Synthesis:
2-[1-(Methylamino)ethyl]indole is used as a key intermediate for the synthesis of various pharmaceutical actives, contributing to the development of new medications and therapeutic agents.
Used in Synthesis of 3-amino-5H-pyrido[4,3-b]indoles:
In the field of organic chemistry, 2-[1-(Methylamino)ethyl]indole is utilized as a precursor in the synthesis of 3-amino-5H-pyrido[4,3-b]indoles, which are a class of compounds with potential applications in medicinal chemistry.
Used in Synthesis of Carcinogenic .gamma.-carbolines:
Although 2-[1-(Methylamino)ethyl]indole has applications in the synthesis of .gamma.-carbolines, it is important to note that these compounds are known to be carcinogenic, and their use should be carefully considered and regulated in research and industrial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 96286-08-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,2,8 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 96286-08:
(7*9)+(6*6)+(5*2)+(4*8)+(3*6)+(2*0)+(1*8)=167
167 % 10 = 7
So 96286-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2/c1-8(12-2)11-7-9-5-3-4-6-10(9)13-11/h3-8,12-13H,1-2H3
96286-08-7Relevant articles and documents
Synthesis of 3-Amino-5H-pyridoindoles, Carcinogenic γ-Carbolines
Akimoto, Hiroshi,Kawai, Akiyoshi,Nomura,Hiroaki
, p. 123 - 130 (2007/10/02)
The carcinogenic γ-carbolines 3-amino-1,4-dimethyl-5H-pyridoindole (1) and 3-amino-1-methyl-5H-pyridoindole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-γ-carbolines.This was followed by dehydrogenation to the γ-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of γ-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-indoles.
