96314-28-2 Usage
Description
(2S,4R)-1-(tert-butoxycarbonyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid is a chiral intermediate compound that plays a crucial role in the synthesis of various pharmaceuticals, particularly in the production of Fosinopril-d5 Sodium Salt, a labeled analogue of Fosinopril Sodium Salt, which is an angiotensin-converting enzyme (ACE) inhibitor used for treating hypertension.
Uses
Used in Pharmaceutical Industry:
(2S,4R)-1-(tert-butoxycarbonyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid is used as a key intermediate in the synthesis of Fosinopril-d5 Sodium Salt, a labeled analogue of Fosinopril Sodium Salt. (2S,4R)-1-(tert-butoxycarbonyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid is essential for the development of antihypertensive medications, as it contributes to the production of ACE inhibitors that help regulate blood pressure and manage hypertension effectively.
Check Digit Verification of cas no
The CAS Registry Mumber 96314-28-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,3,1 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 96314-28:
(7*9)+(6*6)+(5*3)+(4*1)+(3*4)+(2*2)+(1*8)=142
142 % 10 = 2
So 96314-28-2 is a valid CAS Registry Number.
96314-28-2Relevant articles and documents
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs
Ahmed, Adil,Anderson, Niall A.,Benowitz, Andrew B.,Cryan, Jenni,Dai, Han,McGonagle, Grant A.,Rozier, Christine
, (2020/03/23)
Inhibitors of CDK4 and CDK6 have emerged as important FDA-approved treatment options for breast cancer patients. The properties and pharmacology of CDK4/6 inhibitor medicines have been extensively profiled, and investigations into the degradation of these
LITHIUM DIPHENYLCUPRATE REACTIONS WITH 4-TOSYLOXY-L-PROLINES; AN INTERESTING STEREOCHEMICAL OUTCOME. A SYNTHESIS OF TRANS-4-PHENYL-L-PROLINE.
Thottathil, John K.,Moniot, Jerome L.
, p. 151 - 154 (2007/10/02)
The reaction of lithium diphenylcuprate with trans-4- and cis-4-tosyloxy-L-prolines gives excellent yields of 4-phenyl substituted L-prolines and the reaction proceeds with net retention of configuration at the carbon center bearing the tosyloxy group.